Sandbox 171: Difference between revisions
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===Structure=== | ===Structure=== | ||
Myosin has a molecular size of approximately 520 kilodaltons, with two 220 kD heavy chains and two pairs of light chains which vary in size. <ref name="Rayment">PMID: 8316857</ref> The molecule is asymmetric, having a long tail and two globular heads. <ref name="Rayment" /> | Myosin has a molecular size of approximately 520 kilodaltons, with two 220 kD heavy chains and two pairs of light chains which vary in size. <ref name="Rayment">PMID: 8316857</ref> The molecule is asymmetric, having a long tail and two globular heads. <ref name="Rayment" /> Each heavy chains composes the bulk of one of the globular heads. <ref name="Rayment" /> Subfragment-1(S1) also termed the myosin head consists of ATP, actin, and two light chain binding sites.<ref name="Rayment" /> Each globular head has a heavy chain and two light chains for a combined molecular size of about 130 kD. <ref name="Rayment" /> | ||
[[Image:Myosin_head.gif|thumb|alt=Alt text|Myosin head]] | [[Image:Myosin_head.gif|thumb|alt=Alt text|Myosin head]] | ||
[[Image:Myosin_chains.gif|thumb|alt=Alt text|Myosin filament]] | [[Image:Myosin_chains.gif|thumb|alt=Alt text|Myosin filament]] | ||
Revision as of 03:48, 1 April 2010
| Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof. Andrea Gorrell. |
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| 2mys, resolution 2.80Å (default scene) | |||||||||||||
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| Ligands: | MG, SO4 | ||||||||||||
| Non-Standard Residues: | MLY | ||||||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Myosin is one of three major classes of molecular motors: myosin, dynein, and kinesin. As the most abundant of these proteins myosin plays a structural and enzymatic role in muscle contraction and intracellular motility.
Structure
Myosin has a molecular size of approximately 520 kilodaltons, with two 220 kD heavy chains and two pairs of light chains which vary in size. [1] The molecule is asymmetric, having a long tail and two globular heads. [1] Each heavy chains composes the bulk of one of the globular heads. [1] Subfragment-1(S1) also termed the myosin head consists of ATP, actin, and two light chain binding sites.[1] Each globular head has a heavy chain and two light chains for a combined molecular size of about 130 kD. [1]
