3kwu: Difference between revisions
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{{STRUCTURE_3kwu| PDB=3kwu | SCENE= }} | {{STRUCTURE_3kwu| PDB=3kwu | SCENE= }} | ||
===Munc13-1 C2B-domain, calcium bound=== | ===Munc13-1 C2B-domain, calcium bound=== | ||
{{ABSTRACT_PUBMED_20154707}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/UN13A_RAT UN13A_RAT]] Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Also involved in secretory granule priming in insulin secretion.<ref>PMID:9697857</ref> <ref>PMID:11343654</ref> <ref>PMID:11792326</ref> | |||
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==About this Structure== | ==About this Structure== | ||
[[3kwu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KWU OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020154707</ref><references group="xtra"/><references/> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Lu, J.]] | [[Category: Lu, J.]] | ||
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[[Category: Metal binding protein]] | [[Category: Metal binding protein]] | ||
[[Category: Phospholipid binding protein]] | [[Category: Phospholipid binding protein]] | ||