3jyj: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
{{Seed}}
[[Image:3jyj.jpg|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_3jyj", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_3jyj|  PDB=3jyj  |  SCENE=  }}  
{{STRUCTURE_3jyj|  PDB=3jyj  |  SCENE=  }}  
===Structure-Based Design of Novel PIN1 Inhibitors (II)===
===Structure-Based Design of Novel PIN1 Inhibitors (II)===
{{ABSTRACT_PUBMED_20207139}}


 
==Function==
<!--  
[[http://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN]] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref><ref>PMID:16644721</ref><ref>PMID:21497122</ref>  
The line below this paragraph, {{ABSTRACT_PUBMED_20207139}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20207139 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_20207139}}


==About this Structure==
==About this Structure==
3JYJ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JYJ OCA].  
[[3jyj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JYJ OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20207139</ref><references group="xtra"/>
<ref group="xtra">PMID:020207139</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Peptidylprolyl isomerase]]
Line 36: Line 23:
[[Category: Sbdd]]
[[Category: Sbdd]]
[[Category: Small molecule]]
[[Category: Small molecule]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr  7 10:36:02 2010''
Retrieved from "https://proteopedia.org/3jyj"