Group:SMART:2010 Pingry SMART Team: Difference between revisions
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<scene name='2010_Pingry_SMART_Team/1k8c_default/16'>Glu227</scene> changes its interactions with the cofactor depending upon if the cofactor is NAD+ or NADP+, it has water-mediated reaction with the 3-prime alcohol group on the ribose. Similarly, <scene name='2010_Pingry_SMART_Team/1k8c_default/20'> Arg280 </scene> changes position and interacts differently with the two cofactors. <scene name='2010_Pingry_SMART_Team/1k8c_default/13'>Asn276</scene> employs hydrogen bonds with the different cofactors. The relative location on the cofacor differs in NAD+ and NADP+. | <scene name='2010_Pingry_SMART_Team/1k8c_default/16'>Glu227</scene> changes its interactions with the cofactor depending upon if the cofactor is NAD+ or NADP+, it has water-mediated reaction with the 3-prime alcohol group on the ribose. Similarly, <scene name='2010_Pingry_SMART_Team/1k8c_default/20'> Arg280 </scene> changes position and interacts differently with the two cofactors. <scene name='2010_Pingry_SMART_Team/1k8c_default/13'>Asn276</scene> employs hydrogen bonds with the different cofactors. The relative location on the cofacor differs in NAD+ and NADP+. | ||
Asn276 and Ser275 interact only with NADP+ cofactor. Ser275 turns away when NAD+ is present, due to losing its phosphate interactions. | |||
<scene name='2010_Pingry_SMART_Team/1k8c_default/5'>Lys274</scene> interacts with the 2-prime alcohol group on the NADP+ ribose but turns away and does not interact when NAD+ is the cofactor. <scene name='2010_Pingry_SMART_Team/1k8c_default/22'>Ser275</scene> interacts with an oxygen on the phosphate group on the ribose of NADP+ but similarly to the Lys274, does not interact with the NAD+ cofactor. | <scene name='2010_Pingry_SMART_Team/1k8c_default/5'>Lys274</scene> interacts with the 2-prime alcohol group on the NADP+ ribose but turns away and does not interact when NAD+ is the cofactor. <scene name='2010_Pingry_SMART_Team/1k8c_default/22'>Ser275</scene> interacts with an oxygen on the phosphate group on the ribose of NADP+ but similarly to the Lys274, does not interact with the NAD+ cofactor. | ||
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{{Clear}} | {{Clear}} | ||
====PDB ID: 1mi3, Xylose reductase with NAD+==== | ====PDB ID: 1mi3, Xylose reductase with NAD+==== | ||
<applet load='1MI3_chainA.pdb' size='400' frame='true' align='left' caption='1mi3, Xylose reductase with NAD+' scene='2010_Pingry_SMART_Team/1mi3_nospindefault/1'/> | <applet load='1MI3_chainA.pdb' size='400' frame='true' align='left' caption='1mi3, Xylose reductase with NAD+' scene='2010_Pingry_SMART_Team/1mi3_nospindefault/1'/> | ||
