3l9j: Difference between revisions

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{{Seed}}
[[Image:3l9j.png|left|200px]]
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{{STRUCTURE_3l9j|  PDB=3l9j  |  SCENE=  }}  
{{STRUCTURE_3l9j|  PDB=3l9j  |  SCENE=  }}  
===Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex===
===Selection of a novel highly specific TNFalpha antagonist: Insight from the crystal structure of the antagonist-TNFalpha complex===
{{ABSTRACT_PUBMED_20179326}}


==Disease==
[[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:[http://omim.org/entry/607507 607507]]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_20179326}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/TNFA_HUMAN TNFA_HUMAN]] Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.<ref>PMID:16829952</ref>  The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.<ref>PMID:16829952</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 20179326 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20179326}}


==About this Structure==
==About this Structure==
3L9J is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9J OCA].  
[[3l9j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9J OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20179326</ref><references group="xtra"/>
<ref group="xtra">PMID:020179326</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Andersen, M H.]]
[[Category: Andersen, M H.]]
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[[Category: In vitro selection]]
[[Category: In vitro selection]]
[[Category: Lipoprotein]]
[[Category: Lipoprotein]]
[[Category: Polymorphism]]
[[Category: Secreted]]
[[Category: Secreted]]
[[Category: Signal-anchor]]
[[Category: Signal-anchor]]
[[Category: Tnf-alpha]]
[[Category: Tnf-alpha]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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