Factor Xa: Difference between revisions

@@ Line 1: / Line 1: @@
 ==Introduction==
-Factor X is a vitamin K-dependent glycoprotein (Mr= 59000) that is synthesized in the liver. Zymogen factor X circulates in plasma as a 2 chain molecule composed of disulfide linked light (Mr = 16500) and heavy chains (Mr = 42,000). Factor X is activated to factor Xa by cleavage of the activation peptide. This reaction is catalyzed by factor VIIa-tissue factor, of the extrinsic pathway, and factor IXa-factor VIIIa, of the intrinsic pathway.
+Factor X is a vitamin K-dependent glycoprotein that is synthesized in the liver. Zymogen factor X circulates in plasma as a 2 chain molecule composed of a disulfide linked light chain (Mr = 16500) and heavy chain (Mr = 42,000). Factor X is activated to factor Xa by cleavage of the activation peptide. This reaction is catalyzed by factor VIIa-tissue factor (extrinsic Xase complex) and factor IXa-factor VIIIa (intrinsic Xase complex).
+Factor Xa, along with [[factor Va]], calcium, and a phospholipid membrane surface form the prothrombinase complex, to cleave prothrombin to its active form, [[thrombin]].
 ==Structure==

Navigation menu