3ho5: Difference between revisions

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{{Seed}}
[[Image:3ho5.png|left|200px]]
[[Image:3ho5.png|left|200px]]


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{{STRUCTURE_3ho5|  PDB=3ho5  |  SCENE=  }}  
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===Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex===
===Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex===


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{{ABSTRACT_PUBMED_19561609}}
{{ABSTRACT_PUBMED_19561609}}
==Disease==
Known disease associated with this structure: Coloboma, ocular OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]], Holoprosencephaly-3 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]], Microphthalmia, isolated, with coloboma 5 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]], Solitary median maxillary central incisor OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600725 600725]]


==About this Structure==
==About this Structure==
3HO5 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HO5 OCA].  
[[3ho5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HO5 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:19561609</ref><references group="xtra"/>
<ref group="xtra">PMID:019561609</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bosanac, I.]]
[[Category: Bosanac, I.]]
[[Category: Hymowitz, S G.]]
[[Category: Hymowitz, S G.]]
[[Category: Alternative splicing]]
[[Category: Autocatalytic cleavage]]
[[Category: Autocatalytic cleavage]]
[[Category: Calcium cation]]
[[Category: Calcium cation]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]
[[Category: Cytoplasm]]
[[Category: Developmental protein]]
[[Category: Developmental protein]]
[[Category: Disease mutation]]
[[Category: Disease mutation]]
Line 47: Line 30:
[[Category: Microphthalmia]]
[[Category: Microphthalmia]]
[[Category: Palmitate]]
[[Category: Palmitate]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Receptor ectodomain]]
[[Category: Receptor ectodomain]]
Line 54: Line 36:
[[Category: Six-bladed-propeller domain]]
[[Category: Six-bladed-propeller domain]]
[[Category: Zinc cation]]
[[Category: Zinc cation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:48:23 2010''

Revision as of 14:56, 6 March 2013

File:3ho5.png

Template:STRUCTURE 3ho5

Crystal structure of Hedgehog-interacting protein (HHIP) and Sonic hedgehog (SHH) complex

Template:ABSTRACT PUBMED 19561609

About this Structure

3ho5 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Bosanac I, Maun HR, Scales SJ, Wen X, Lingel A, Bazan JF, de Sauvage FJ, Hymowitz SG, Lazarus RA. The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling. Nat Struct Mol Biol. 2009 Jul;16(7):691-7. Epub 2009 Jun 28. PMID:19561609 doi:10.1038/nsmb.1632

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