3m0a: Difference between revisions
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{{STRUCTURE_3m0a| PDB=3m0a | SCENE= }} | {{STRUCTURE_3m0a| PDB=3m0a | SCENE= }} | ||
===Crystal structure of TRAF2:cIAP2 complex=== | ===Crystal structure of TRAF2:cIAP2 complex=== | ||
{{ABSTRACT_PUBMED_20385093}} | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/BIRC3_HUMAN BIRC3_HUMAN]] Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TRAF2_HUMAN TRAF2_HUMAN]] Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain.<ref>PMID:10346818</ref><ref>PMID:11907583</ref><ref>PMID:12917689</ref><ref>PMID:15383523</ref><ref>PMID:19506082</ref><ref>PMID:19150425</ref><ref>PMID:18981220</ref><ref>PMID:19918265</ref><ref>PMID:20064526</ref><ref>PMID:19937093</ref><ref>PMID:20047764</ref><ref>PMID:20577214</ref><ref>PMID:19810754</ref><ref>PMID:20385093</ref> [[http://www.uniprot.org/uniprot/BIRC3_HUMAN BIRC3_HUMAN]] Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.<ref>PMID:21931591</ref> | |||
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==About this Structure== | ==About this Structure== | ||
[[3m0a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M0A OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020385093</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kabaleeswaran, V.]] | [[Category: Kabaleeswaran, V.]] | ||
[[Category: Wu, H.]] | [[Category: Wu, H.]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
[[Category: Traf2: ciap2 and the traf1: traf2: ciap2 complex]] | [[Category: Traf2: ciap2 and the traf1: traf2: ciap2 complex]] | ||
