3lbz: Difference between revisions

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{{Seed}}
[[Image:3lbz.jpg|left|200px]]
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{{STRUCTURE_3lbz|  PDB=3lbz  |  SCENE=  }}  
{{STRUCTURE_3lbz|  PDB=3lbz  |  SCENE=  }}  
===Crystal Structure of the BCL6 BTB domain complexed with the small molecule inhibitor 79-6===
===Crystal Structure of the BCL6 BTB domain complexed with the small molecule inhibitor 79-6===
{{ABSTRACT_PUBMED_20385364}}


==Disease==
[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.  Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.  Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_20385364}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN]] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref><ref>PMID:18280243</ref>  
(as it appears on PubMed at http://www.pubmed.gov), where 20385364 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20385364}}


==About this Structure==
==About this Structure==
3LBZ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LBZ OCA].  
[[3lbz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LBZ OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20385364</ref><references group="xtra"/>
<ref group="xtra">PMID:020385364</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Ghetu, A F.]]
[[Category: Ghetu, A F.]]
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:56:57 2010''
Retrieved from "https://proteopedia.org/3lbz"