3l6b: Difference between revisions

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{{Seed}}
[[Image:3l6b.png|left|200px]]
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{{STRUCTURE_3l6b|  PDB=3l6b  |  SCENE=  }}  
{{STRUCTURE_3l6b|  PDB=3l6b  |  SCENE=  }}  
===X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor===
===X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor===
{{ABSTRACT_PUBMED_20106978}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/SRR_HUMAN SRR_HUMAN]] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:11054547</ref> <ref>PMID:20106978</ref>
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{{ABSTRACT_PUBMED_20106978}}


==About this Structure==
==About this Structure==
3L6B is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6B OCA].  
[[3l6b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6B OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20106978</ref><references group="xtra"/>
<ref group="xtra">PMID:020106978</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Serine racemase]]
[[Category: Serine racemase]]
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[[Category: Pyridoxal phosphate]]
[[Category: Pyridoxal phosphate]]
[[Category: Serine racemase]]
[[Category: Serine racemase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:27:09 2010''

Revision as of 20:20, 4 April 2013

Template:STRUCTURE 3l6b

X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor

Template:ABSTRACT PUBMED 20106978

Function

[SRR_HUMAN] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.[1] [2]

About this Structure

3l6b is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062
  1. ↑ De Miranda J, Santoro A, Engelender S, Wolosker H. Human serine racemase: moleular cloning, genomic organization and functional analysis. Gene. 2000 Oct 3;256(1-2):183-8. PMID:11054547
  2. ↑ Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062

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