3kvc: Difference between revisions
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{{STRUCTURE_3kvc| PDB=3kvc | SCENE= }} | {{STRUCTURE_3kvc| PDB=3kvc | SCENE= }} | ||
===Crystal structure of bovine RPE65 at 1.9 angstrom resolution=== | ===Crystal structure of bovine RPE65 at 1.9 angstrom resolution=== | ||
{{ABSTRACT_PUBMED_20100834}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RPE65_BOVIN RPE65_BOVIN]] Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.<ref>PMID:16096063</ref> <ref>PMID:19805034</ref> <ref>PMID:20100834</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3kvc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVC OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020100834</ref><references group="xtra"/><references/> | ||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Golczak, M.]] | [[Category: Golczak, M.]] | ||
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[[Category: Palczewski, K.]] | [[Category: Palczewski, K.]] | ||
[[Category: 7-bladed beta-propeller]] | [[Category: 7-bladed beta-propeller]] | ||
[[Category: Cell membrane]] | [[Category: Cell membrane]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Iron]] | [[Category: Iron]] | ||
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[[Category: Sensory transduction]] | [[Category: Sensory transduction]] | ||
[[Category: Vision]] | [[Category: Vision]] | ||