3l6c: Difference between revisions
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{{STRUCTURE_3l6c| PDB=3l6c | SCENE= }} | {{STRUCTURE_3l6c| PDB=3l6c | SCENE= }} | ||
===X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor=== | ===X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor=== | ||
{{ABSTRACT_PUBMED_20106978}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SRR_RAT SRR_RAT]] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.<ref>PMID:16713567</ref> <ref>PMID:20106978</ref> | |||
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==About this Structure== | ==About this Structure== | ||
[[3l6c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L6C OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020106978</ref><references group="xtra"/><references/> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Serine racemase]] | [[Category: Serine racemase]] | ||
| Line 40: | Line 27: | ||
[[Category: Pyridoxal phosphate]] | [[Category: Pyridoxal phosphate]] | ||
[[Category: Serine racemase]] | [[Category: Serine racemase]] | ||
Revision as of 20:50, 4 April 2013
X-ray crystal structure of rat serine racemase in complex with malonate a potent inhibitor
Template:ABSTRACT PUBMED 20106978
Function
[SRR_RAT] Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine.[1] [2]
About this Structure
3l6c is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062
- ↑ Panatier A, Theodosis DT, Mothet JP, Touquet B, Pollegioni L, Poulain DA, Oliet SH. Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell. 2006 May 19;125(4):775-84. PMID:16713567 doi:10.1016/j.cell.2006.02.051
- ↑ Smith MA, Mack V, Ebneth A, Moraes I, Felicetti B, Wood M, Schonfeld D, Mather O, Cesura A, Barker J. The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J Biol Chem. 2010 Apr 23;285(17):12873-81. Epub 2010 Jan 27. PMID:20106978 doi:10.1074/jbc.M109.050062
