Reverse transcriptase: Difference between revisions
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==Structure== | ==Structure== | ||
This ''hand-like'' <scene name='Reverse_transcriptase/Chains/1'>heterodimer</scene> protein that has an usual length of 1000 residues (560 in Chain A and 440 for B), the third of them involved in alpha helical and almost a quarter in beta sheets, showing α+β <scene name='Reverse_transcriptase/Secondary/1'>secondary structure</scene> domains; <scene name='Reverse_transcriptase/Chaina/1'>Chain A</scene> has an usual weight of 66KDa whereas <scene name='Reverse_transcriptase/Chainb/1'>Chain B</scene> is around 51KDa, those monomers are derived from the same gen but p51 lacks the aminoacids of one active site and has a different tertiary structure conformation compared with p66, for this reason is totally inactive. [http://www.sciencemag.org.silk.library.umass.edu:2048/cgi/content/abstract/sci;256/5065/1783?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&volume=256&firstpage=1783&resourcetype=HWCIT] | This ''hand-like'' <scene name='Reverse_transcriptase/Chains/1'>heterodimer</scene> protein that has an usual length of 1000 residues (560 in Chain A and 440 for B), the third of them involved in alpha helical and almost a quarter in beta sheets, showing α+β <scene name='Reverse_transcriptase/Secondary/1'>secondary structure</scene> domains; <scene name='Reverse_transcriptase/Chaina/1'>Chain A</scene> has an usual weight of 66KDa whereas <scene name='Reverse_transcriptase/Chainb/1'>Chain B</scene> is around 51KDa, those monomers are derived from the same gen but p51 lacks the aminoacids of one active site and has a different tertiary structure conformation compared with p66, for this reason is totally inactive. [http://www.sciencemag.org.silk.library.umass.edu:2048/cgi/content/abstract/sci;256/5065/1783?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexacttitleabs=and&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&volume=256&firstpage=1783&resourcetype=HWCIT] | ||
{{STRUCTURE_3hvt| PDB=3jyt | SCENE='Reverse_transcriptase/Initial/1' size='[450,338]' align='right' caption='Reverse Transcriptase' }} | |||
{{STRUCTURE_3hvt| PDB=3jyt | SCENE='Reverse_transcriptase/Initial/1' size='[450,338]' align='right' | |||
==Function== | ==Function== | ||
