3ld6: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
{{Seed}}
[[Image:3ld6.png|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_3ld6", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_3ld6|  PDB=3ld6  |  SCENE=  }}  
{{STRUCTURE_3ld6|  PDB=3ld6  |  SCENE=  }}  
===Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole===
===Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole===
{{ABSTRACT_PUBMED_20149798}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/CP51A_HUMAN CP51A_HUMAN]] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
The line below this paragraph, {{ABSTRACT_PUBMED_20149798}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20149798 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_20149798}}


==About this Structure==
==About this Structure==
3LD6 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3i3k 3i3k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD6 OCA].  
[[3ld6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3i3k 3i3k]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LD6 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20149798</ref><references group="xtra"/>
<ref group="xtra">PMID:020149798</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Sterol 14-demethylase]]
[[Category: Sterol 14-demethylase]]
Line 35: Line 22:
[[Category: Tempel, W.]]
[[Category: Tempel, W.]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
[[Category: Alternative splicing]]
[[Category: Cholesterol biosynthesis]]
[[Category: Cholesterol biosynthesis]]
[[Category: Cytochrome p450]]
[[Category: Cytochrome p450]]
Line 49: Line 35:
[[Category: Nadp]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Polymorphism]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Steroid biosynthesis]]
[[Category: Steroid biosynthesis]]
Line 57: Line 42:
[[Category: Structural genomics consortium]]
[[Category: Structural genomics consortium]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 08:58:41 2010''

Revision as of 19:58, 4 April 2013

Template:STRUCTURE 3ld6

Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with ketoconazole

Template:ABSTRACT PUBMED 20149798

Function

[CP51A_HUMAN] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.

About this Structure

3ld6 is a 2 chain structure with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 3i3k. Full crystallographic information is available from OCA.

Reference

  1. Strushkevich N, Usanov SA, Park HW. Structural basis of human CYP51 inhibition by antifungal azoles. J Mol Biol. 2010 Apr 9;397(4):1067-78. Epub 2010 Feb 10. PMID:20149798 doi:10.1016/j.jmb.2010.01.075

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=3ld6&oldid=1770483"