3l4c: Difference between revisions
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{{STRUCTURE_3l4c| PDB=3l4c | SCENE= }} | {{STRUCTURE_3l4c| PDB=3l4c | SCENE= }} | ||
===Structural basis of membrane-targeting by Dock180=== | ===Structural basis of membrane-targeting by Dock180=== | ||
{{ABSTRACT_PUBMED_20167601}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DOCK1_HUMAN DOCK1_HUMAN]] Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.<ref>PMID:8657152</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3l4c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4C OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020167601</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bankston, L A.]] | [[Category: Bankston, L A.]] | ||
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[[Category: Cell migration]] | [[Category: Cell migration]] | ||
[[Category: Cell polarity]] | [[Category: Cell polarity]] | ||
[[Category: Cytoskeleton]] | [[Category: Cytoskeleton]] | ||
[[Category: Dock1]] | [[Category: Dock1]] | ||
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[[Category: Sh3 domain]] | [[Category: Sh3 domain]] | ||
[[Category: Sh3-binding]] | [[Category: Sh3-binding]] | ||