3lms: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_3lms| PDB=3lms | SCENE= }} | {{STRUCTURE_3lms| PDB=3lms | SCENE= }} | ||
===Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.=== | ===Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.=== | ||
{{ABSTRACT_PUBMED_20088943}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CBPB2_HUMAN CBPB2_HUMAN]] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.<ref>PMID:10574983</ref> | |||
--> | |||
==About this Structure== | ==About this Structure== | ||
[[3lms]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rhipicephalus_bursa Rhipicephalus bursa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LMS OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020088943</ref><references group="xtra"/><references/> | ||
[[Category: Carboxypeptidase U]] | [[Category: Carboxypeptidase U]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| Line 34: | Line 21: | ||
[[Category: Valnickova, Z.]] | [[Category: Valnickova, Z.]] | ||
[[Category: Alpha-beta-hydrolase]] | [[Category: Alpha-beta-hydrolase]] | ||
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
[[Category: Carboxypeptidase]] | [[Category: Carboxypeptidase]] | ||
| Line 49: | Line 35: | ||
[[Category: Metalloprotease]] | [[Category: Metalloprotease]] | ||
[[Category: Metalloprotease inhibitor]] | [[Category: Metalloprotease inhibitor]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
Revision as of 23:21, 10 April 2013
Structure of human activated thrombin-activatable fibrinolysis inhibitor, TAFIa, in complex with tick-derived funnelin inhibitor, TCI.
Template:ABSTRACT PUBMED 20088943
Function
[CBPB2_HUMAN] Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.[1]
About this Structure
3lms is a 2 chain structure with sequence from Homo sapiens and Rhipicephalus bursa. Full crystallographic information is available from OCA.
Reference
- Sanglas L, Arolas JL, Valnickova Z, Aviles FX, Enghild JJ, Gomis-Ruth FX. Insights into the molecular inactivation mechanism of human activated thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost. 2010 May;8(5):1056-65. Epub 2010 Jan 17. PMID:20088943 doi:10.1111/j.1538-7836.2010.03740.x
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Carboxypeptidase U
- Homo sapiens
- Rhipicephalus bursa
- Arolas, J L.
- Aviles, F X.
- Enghild, J J.
- Gomis-Ruth, F X.
- Sanglas, L.
- Valnickova, Z.
- Alpha-beta-hydrolase
- Blood coagulation
- Carboxypeptidase
- Cogaulation
- Disulfide bond
- Fibrinolysis
- Funnelin
- Glycoprotein
- Hydrolase
- Hydrolase-hydrolase inhibitor complex
- Metal-binding
- Metalloenzyme inhibitor
- Metallopeptidase
- Metalloprotease
- Metalloprotease inhibitor
- Protease
- Secreted
- Zymogen
