3lw8: Difference between revisions

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{{Seed}}
[[Image:3lw8.png|left|200px]]
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{{STRUCTURE_3lw8|  PDB=3lw8  |  SCENE=  }}  
{{STRUCTURE_3lw8|  PDB=3lw8  |  SCENE=  }}  
===Shigella IpgB2 in complex with human RhoA, GDP and Mg2+ (complex A)===
===Shigella IpgB2 in complex with human RhoA, GDP and Mg2+ (complex A)===
{{ABSTRACT_PUBMED_20363740}}


 
==Function==
<!--  
[[http://www.uniprot.org/uniprot/RHOA_HUMAN RHOA_HUMAN]] Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.<ref>PMID:8910519</ref> <ref>PMID:9121475</ref> <ref>PMID:12900402</ref> <ref>PMID:16103226</ref> <ref>PMID:16236794</ref> <ref>PMID:19934221</ref> <ref>PMID:20937854</ref> <ref>PMID:20974804</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_20363740}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_20363740}}


==About this Structure==
==About this Structure==
3LW8 is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW8 OCA].  
[[3lw8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW8 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20363740</ref><references group="xtra"/>
<ref group="xtra">PMID:020363740</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
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[[Category: Ttss effector protein]]
[[Category: Ttss effector protein]]
[[Category: Wxxxe]]
[[Category: Wxxxe]]
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