3l8i: Difference between revisions

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{{Seed}}
[[Image:3l8i.png|left|200px]]
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{{STRUCTURE_3l8i|  PDB=3l8i  |  SCENE=  }}  
{{STRUCTURE_3l8i|  PDB=3l8i  |  SCENE=  }}  
===Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity===
===Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity===
{{ABSTRACT_PUBMED_20489202}}


==Disease==
[[http://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Hereditary cerebral cavernous malformation. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3) [MIM:[http://omim.org/entry/603285 603285]]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.<ref>PMID:15543491</ref> 


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_20489202}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/PDC10_HUMAN PDC10_HUMAN]] Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity).<ref>PMID:15543491</ref> <ref>PMID:17360971</ref> <ref>PMID:20332113</ref>
(as it appears on PubMed at http://www.pubmed.gov), where 20489202 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20489202}}


==About this Structure==
==About this Structure==
3L8I is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8I OCA].  
[[3l8i]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L8I OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20489202</ref><references group="xtra"/>
<ref group="xtra">PMID:020489202</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Boggon, T J.]]
[[Category: Boggon, T J.]]
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[[Category: Fat domain]]
[[Category: Fat domain]]
[[Category: Protein binding]]
[[Category: Protein binding]]
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