3i25: Difference between revisions

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{{Seed}}
[[Image:3i25.png|left|200px]]
[[Image:3i25.jpg|left|200px]]


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{{STRUCTURE_3i25|  PDB=3i25  |  SCENE=  }}  
{{STRUCTURE_3i25|  PDB=3i25  |  SCENE=  }}  


===Potent Beta-Secretase 1 hydroxyethylene Inhibitor===
===Potent Beta-Secretase 1 hydroxyethylene Inhibitor===


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{{ABSTRACT_PUBMED_20122837}}
{{ABSTRACT_PUBMED_20122837}}


==About this Structure==
==About this Structure==
3I25 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I25 OCA].  
[[3i25]] is a 3 chain structure of [[Beta secretase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I25 OCA].  
 
==See Also==
*[[Beta secretase|Beta secretase]]


==Reference==
==Reference==
<ref group="xtra">PMID:20122837</ref><references group="xtra"/>
<ref group="xtra">PMID:020122837</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Memapsin 2]]
[[Category: Memapsin 2]]
Line 29: Line 20:
[[Category: Lindberg, J D.]]
[[Category: Lindberg, J D.]]
[[Category: Nystrom, S.]]
[[Category: Nystrom, S.]]
[[Category: Alternative splicing]]
[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
[[Category: Bace]]
[[Category: Bace]]
Line 38: Line 28:
[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun  2 08:34:50 2010''

Revision as of 17:18, 25 July 2012

File:3i25.png

Template:STRUCTURE 3i25

Potent Beta-Secretase 1 hydroxyethylene Inhibitor

Template:ABSTRACT PUBMED 20122837

About this Structure

3i25 is a 3 chain structure of Beta secretase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  1. Bjorklund C, Adolfsson H, Jansson K, Lindberg J, Vrang L, Hallberg A, Rosenquist S, Samuelsson B. Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core. Bioorg Med Chem. 2010 Feb 15;18(4):1711-23. Epub 2010 Jan 11. PMID:20122837 doi:10.1016/j.bmc.2009.12.051

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