User:Wayne Decatur/Suppression of RNA Silencing by Viruses: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m editing overview |
mNo edit summary |
||
| Line 16: | Line 16: | ||
==Overview== | ==Overview== | ||
Andrew Z. Fire and Craig C. Mello shared [http://nobelprize.org/nobel_prizes/medicine/laureates/2006/ the 2006 Nobel Prize in Medicine or Physiology] for their discovery of [ | Andrew Z. Fire and Craig C. Mello shared [http://nobelprize.org/nobel_prizes/medicine/laureates/2006/ the 2006 Nobel Prize in Medicine or Physiology] for their discovery of [[RNA interference]] - gene silencing by double-stranded RNA.<br> | ||
RNA interference (RNAi) (also known as [http://en.wikipedia.org/wiki/Post-transcriptional_gene_silencing post-transcriptional gene silencing (PTGS)] or [http://en.wikipedia.org/wiki/RNA_Silencing RNA silencing]) is an evolutionarily conserved cellular response to the presence of double-stranded (ds) RNA that functions as a gene inactivation system in many eukaryotes and relies on tiny RNAs as the targeting molecules. One function of RNA silencing is to act in surveillance against molecular parasites, such as viruses, several of which rely on double-stranded RNA for replication. Viruses have developed mechanisms to counteract RNAi by providing proteins that sequester the tiny [http://en.wikipedia.org/wiki/Small_interfering_RNA silencing RNAs (siRNAs)] targeted against viral RNAs.<br> | RNA interference (RNAi) (also known as [http://en.wikipedia.org/wiki/Post-transcriptional_gene_silencing post-transcriptional gene silencing (PTGS)] or [http://en.wikipedia.org/wiki/RNA_Silencing RNA silencing]) is an evolutionarily conserved cellular response to the presence of double-stranded (ds) RNA that functions as a gene inactivation system in many eukaryotes and relies on tiny RNAs as the targeting molecules. One function of RNA silencing is to act in surveillance against molecular parasites, such as viruses, several of which rely on double-stranded RNA for replication. Viruses have developed mechanisms to counteract RNAi by providing proteins that sequester the tiny [http://en.wikipedia.org/wiki/Small_interfering_RNA silencing RNAs (siRNAs)] targeted against viral RNAs.<br> | ||
