3n1f: Difference between revisions
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{{STRUCTURE_3n1f| PDB=3n1f | SCENE= }} | {{STRUCTURE_3n1f| PDB=3n1f | SCENE= }} | ||
===Crystal Structure of IhhN bound to CDOFn3=== | ===Crystal Structure of IhhN bound to CDOFn3=== | ||
{{ABSTRACT_PUBMED_20519495}} | {{ABSTRACT_PUBMED_20519495}} | ||
==Disease== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:[http://omim.org/entry/614226 614226]]. HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CDON_HUMAN CDON_HUMAN]] Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[3n1f]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1F OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020519495</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kavran, J M.]] | [[Category: Kavran, J M.]] | ||
[[Category: Leahy, D J.]] | [[Category: Leahy, D J.]] | ||
[[Category: Binding site]] | [[Category: Binding site]] | ||
[[Category: Cell adhesion molecule]] | [[Category: Cell adhesion molecule]] | ||
[[Category: Cell cycle protein]] | [[Category: Cell cycle protein]] | ||
| Line 48: | Line 34: | ||
[[Category: Tertiary]] | [[Category: Tertiary]] | ||
[[Category: Tumor suppressor protein]] | [[Category: Tumor suppressor protein]] | ||
Revision as of 03:03, 25 March 2013
Crystal Structure of IhhN bound to CDOFn3
Template:ABSTRACT PUBMED 20519495
Disease
[CDON_HUMAN] Defects in CDON are the cause of holoprosencephaly type 11 (HPE11) [MIM:614226]. HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
Function
[CDON_HUMAN] Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).
About this Structure
3n1f is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. J Biol Chem. 2010 Aug 6;285(32):24584-90. Epub 2010 Jun 1. PMID:20519495 doi:10.1074/jbc.M110.131680
