3mpx: Difference between revisions
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{{STRUCTURE_3mpx| PDB=3mpx | SCENE= }} | {{STRUCTURE_3mpx| PDB=3mpx | SCENE= }} | ||
===Crystal structure of the DH and PH-1 domains of human FGD5=== | ===Crystal structure of the DH and PH-1 domains of human FGD5=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/FGD5_HUMAN FGD5_HUMAN]] Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. | |||
==About this Structure== | ==About this Structure== | ||
[[3mpx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MPX OCA]. | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
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[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Structural genomics consortium]] | [[Category: Structural genomics consortium]] | ||
Revision as of 20:44, 17 April 2013
Crystal structure of the DH and PH-1 domains of human FGD5
Function
[FGD5_HUMAN] Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
About this Structure
3mpx is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
