2c0t: Difference between revisions
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[[Image:2c0t.gif|left|200px]]<br /><applet load="2c0t" size=" | [[Image:2c0t.gif|left|200px]]<br /><applet load="2c0t" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="2c0t, resolution 2.15Å" /> | caption="2c0t, resolution 2.15Å" /> | ||
'''SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359'''<br /> | '''SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2C0T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with CA and L3G as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.10.1_and_2.7.10.2 Transferred entry: 2.7.10.1 and 2.7.10.2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.112 2.7.1.112] Known structural/functional Site: <scene name='pdbsite=AC1:Ca Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http:// | 2C0T is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=L3G:'>L3G</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Transferred_entry:_2.7.10.1_and_2.7.10.2 Transferred entry: 2.7.10.1 and 2.7.10.2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.112 2.7.1.112] Known structural/functional Site: <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+B'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0T OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:30:03 2008'' | ||
Revision as of 08:30, 3 February 2008
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SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359
Overview
We describe the identification, SAR, and pharmacology of the src-family, selective lck inhibitor A-770041 that prolongs the survival of major, histocompatibility mismatched allografts in models of solid organ, transplant rejection for greater than 65 days.
About this Structure
2C0T is a Single protein structure of sequence from Homo sapiens with CA and L3G as ligands. Active as Transferred entry: 2.7.10.1 and 2.7.10.2, with EC number 2.7.1.112 Known structural/functional Site: AC1. Full crystallographic information is available from OCA.
Reference
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497
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Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Homo sapiens
- Single protein
- Transferred entry: 2.7.10.1 and 2.7.10.2
- Borhani, D.W.
- Burchat, A.
- Calderwood, D.J.
- Hirst, G.C.
- Li, B.
- Loew, A.
- CA
- L3G
- Alternative initiation
- Atp-binding
- Kinase
- Lipoprotein
- Myristate
- Nucleotide-binding
- Palmitate
- Phosphorylation
- Sh2 domain
- Sh3 domain
- Transferase
- Tyrosine-protein kinase
