3lwt: Difference between revisions
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{{STRUCTURE_3lwt| PDB=3lwt | SCENE= }} | {{STRUCTURE_3lwt| PDB=3lwt | SCENE= }} | ||
===Crystal structure of the Yeast Sac1: Implications for its phosphoinositide phosphatase function=== | ===Crystal structure of the Yeast Sac1: Implications for its phosphoinositide phosphatase function=== | ||
{{ABSTRACT_PUBMED_20389282}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SAC1_YEAST SAC1_YEAST]] Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton.<ref>PMID:10625610</ref> <ref>PMID:11514624</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3lwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWT OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020389282</ref><references group="xtra"/><references/> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Emr, S D.]] | [[Category: Emr, S D.]] | ||
| Line 40: | Line 27: | ||
[[Category: Sac3/fig4]] | [[Category: Sac3/fig4]] | ||
[[Category: Transmembrane]] | [[Category: Transmembrane]] | ||
Revision as of 23:27, 10 April 2013
Crystal structure of the Yeast Sac1: Implications for its phosphoinositide phosphatase function
Template:ABSTRACT PUBMED 20389282
Function
[SAC1_YEAST] Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. May be involved in the coordination of the activities of the secretory pathway and the actin cytoskeleton.[1] [2]
About this Structure
3lwt is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
- Manford A, Xia T, Saxena AK, Stefan C, Hu F, Emr SD, Mao Y. Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function. EMBO J. 2010 May 5;29(9):1489-98. Epub 2010 Apr 13. PMID:20389282 doi:10.1038/emboj.2010.57
- ↑ Hughes WE, Woscholski R, Cooke FT, Patrick RS, Dove SK, McDonald NQ, Parker PJ. SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases. J Biol Chem. 2000 Jan 14;275(2):801-8. PMID:10625610
- ↑ Foti M, Audhya A, Emr SD. Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol Biol Cell. 2001 Aug;12(8):2396-411. PMID:11514624
