TBX5: Difference between revisions
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Lone TBX5 crystallised with just one TBX5 in the asymmetric unit, failing to form the disulphide bridge as seen in the first crystal structure. However, the region which formed the minor contacts with the other TBX5 in the DNA-bound crystal structure is disordered in this structure, as predicted by the RONN algorithm. Similar disordered predictions are seen in Brachyury, although in the DNA-bound state this has a well-defined electron density (this could be stabilised by the crystal packing, however) and is part of a long loop region. The 3<sub>10</sub>C helix is also disordered in the apo-form of TBX5. | Lone TBX5 crystallised with just one TBX5 in the asymmetric unit, failing to form the disulphide bridge as seen in the first crystal structure. However, the region which formed the minor contacts with the other TBX5 in the DNA-bound crystal structure is disordered in this structure, as predicted by the RONN algorithm. Similar disordered predictions are seen in Brachyury, although in the DNA-bound state this has a well-defined electron density (this could be stabilised by the crystal packing, however) and is part of a long loop region. The 3<sub>10</sub>C helix is also disordered in the apo-form of TBX5. | ||
==Additional Resources== | |||
For additional information, see: [[Transcription and RNA Processing]] | |||
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