3lzc: Difference between revisions
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{{STRUCTURE_3lzc| PDB=3lzc | SCENE= }} | {{STRUCTURE_3lzc| PDB=3lzc | SCENE= }} | ||
===Crystal structure of Dph2 from Pyrococcus horikoshii=== | ===Crystal structure of Dph2 from Pyrococcus horikoshii=== | ||
{{ABSTRACT_PUBMED_20559380}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/O58832_PYRHO O58832_PYRHO]] Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).<ref>PMID:20559380</ref> | |||
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==About this Structure== | ==About this Structure== | ||
[[3lzc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LZC OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020559380</ref><references group="xtra"/><references/> | ||
[[Category: Pyrococcus horikoshii]] | [[Category: Pyrococcus horikoshii]] | ||
[[Category: Dzikovski, B.]] | [[Category: Dzikovski, B.]] | ||
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[[Category: Gene triplication]] | [[Category: Gene triplication]] | ||
[[Category: Radical sam enzyme]] | [[Category: Radical sam enzyme]] | ||
Revision as of 23:27, 10 April 2013
Crystal structure of Dph2 from Pyrococcus horikoshii
Template:ABSTRACT PUBMED 20559380
Function
[O58832_PYRHO] Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).[1]
About this Structure
3lzc is a 2 chain structure with sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.
Reference
- Zhang Y, Zhu X, Torelli AT, Lee M, Dzikovski B, Koralewski RM, Wang E, Freed J, Krebs C, Ealick SE, Lin H. Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature. 2010 Jun 17;465(7300):891-6. PMID:20559380 doi:10.1038/nature09138
- ↑ Zhang Y, Zhu X, Torelli AT, Lee M, Dzikovski B, Koralewski RM, Wang E, Freed J, Krebs C, Ealick SE, Lin H. Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme. Nature. 2010 Jun 17;465(7300):891-6. PMID:20559380 doi:10.1038/nature09138
