Tropomyosin: Difference between revisions

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[[Image:1c1g.png|left|300px]]
[[Image:1c1g.png|left|300px]]
{{STRUCTURE_1c1g|  PDB=1c1g  | SIZE=400| SCENE= |CAPTION=Tropomyosin from ''Sus scrofa'', [[1c1g]] }}
{{STRUCTURE_1c1g|  PDB=1c1g  | SIZE=400| SCENE=Tropomyosin/Cv/1 |CAPTION=Tropomyosin from [http://en.wikipedia.org/wiki/Sus_scrofa ''Sus scrofa''], [[1c1g]] }}


'''3D Structure of Tropomyosin''' <br />
'''3D Structure of Tropomyosin''' <br />
The image at the top is a Tropomyosin from ''Sus scrofa'' ([[1c1g]])
The image at the left is a Tropomyosin from [http://en.wikipedia.org/wiki/Sus_scrofa ''Sus scrofa''] ([[1c1g]]).
 
{{Clear}}
{{Clear}}
== Tropomyosin ==
== Tropomyosin ==


Tropomyosin (TPM) has a 4-helix coiled dimer structure.  It regulates the binding of myosin thus regulating muscle contraction.  In its locked conformation it binds troponin T (TnnT) and prevents the binding of myosin to actin. When Ca+ atoms bind to TnnT, the TPM assumes an open conformation and myosin can bind to actin. You can  <scene name='Tropomyosin/Cv/2'>enlarge the image</scene> at the right for clarity.


Tropomyosin (TPM) has a 4-helix coiled dimer structure.  It regulates the binding of myosin thus regulating muscle contraction.  In its locked conformation it binds troponin T (TnnT) and prevents the binding of myosin to actin.  When Ca+ atoms bind to TnnT, the TPM assumes an open conformation and myosin can bind to actin.




== 3D Structures of Tropomyosin ==
== 3D Structures of Tropomyosin ==


3mtu, 3mud – cTPM alpha-1 – chicken<br />
[[3mtu]], [[3mud]] – cTPM alpha-1 – chicken<br />
1ic2 - cTPM alpha-1 (mutant)<br />
[[1ic2]] - cTPM alpha-1 (mutant)<br />
2w49 – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin<br />
[[2w49]] – cTnnC+cTnnT+cTnnI+cTPM alpha-1+cActin<br />
2z5h – yTPM alpha-1 N-terminal+C-terminal+GNC4+TnnT – yeast<br />
[[2z5h]] – yTPM alpha-1 N-terminal+C-terminal+GNC4+TnnT – yeast<br />
2z5i - yTPM alpha-1 N-terminal+C-terminal+GNC4<br />
[[2z5i]] - yTPM alpha-1 N-terminal+C-terminal+GNC4<br />
2efr, 2efs, 2d3e - rTPM alpha-1 C-terminal+GNC4 – rabbit<br />
[[2efr]], [[2efs]], [[2d3e]] - rTPM alpha-1 C-terminal+GNC4 – rabbit<br />
1kql - TPM alpha-1 C-terminal+GNC4 - rat<br />
[[1kql]] - TPM alpha-1 C-terminal+GNC4 - rat<br />
2b9c – TPM mid region – rat<br />
[[2b9c]] – TPM mid region – rat<br />
1c1g – TPM – pig<br />
[[1c1g]] – TPM – pig<br />
2tma – TPM - model<br />
[[2tma]] – TPM - model<br />
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