Fibrinogen: Difference between revisions
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[[Image:3hus2.jpg|left|300px|thumb|Crystal Structure of Fibrinogen with peptide ligand, [[3hus]]]] | [[Image:3hus2.jpg|left|300px|thumb|Crystal Structure of Fibrinogen with peptide ligand, [[3hus]]]] | ||
<applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/ | <applet load='3hus2.pdb' size='300' frame='true' align='right' scene="Fibrinogen/Starting_scene/1" caption= 'Crystal structure of fibrinogen fragment D with the peptide ligand Gly-Pro-Arg-Pro-amide, [[3hus]]' /> | ||
'''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing Knobs A & B to form fibrin. <ref>PMID:16689770</ref> It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained. <ref>PMID:18673233</ref> | '''Fibrinogen''' is a glycoprotein found in the blood that is converted into fibrin during blood coagulation. Fibrinogen is cleaved by another protein, [[thrombin]], exposing Knobs A & B to form fibrin. <ref>PMID:16689770</ref> It is this fibrin that is linked to clotting factors like factor XIII which form clots to prevent excessive bleeding from wounds sustained. <ref>PMID:18673233</ref> | ||
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==3D Structure of Fibrinogen== | ==3D Structure of Fibrinogen== | ||
Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (Fba, Fbb, Fbg) . | Fibrinogen is composed of 3 non-identical chains alpha, beta, gamma (<scene name='Fibrinogen/Fba/1'>Fba</scene>, <scene name='Fibrinogen/Fbb/1'>Fbb</scene>, <scene name='Fibrinogen/Fbg/1'>Fbg</scene> ) . | ||
===Fibrinogen alpha+beta+gamma chains=== | ===Fibrinogen alpha+beta+gamma chains=== | ||
