User:Wayne Decatur/Sandbox Glutamate receptor: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
|||
| Line 165: | Line 165: | ||
::Note that the M4 segment associates with the ion-channel core of an adjacent subunit. | ::Note that the M4 segment associates with the ion-channel core of an adjacent subunit. | ||
:{{Link Toggle FancyCartoonHighQualityView}}. | :{{Link Toggle FancyCartoonHighQualityView}}. | ||
*The TMD domain of the GluA2 receptor shares structural and sequence similarity with the pore region of the potassium (K+), as hinted at by earlier work<ref name ="pot1">PMID: 7539962</ref><ref name ="pot2">PMID: 7761417</ref><ref name ="pot2">PMID: 9525859</ref>. Here the pore region of ''Streptomyces lividans'' potassium channel ([[1bl8]])<scene name='User:Wayne_Decatur/Sandbox_Glutamate_receptor/Gluvspottmd/4'>superposed with the TMD domain with GluA2</scene>, specifically the inner helix of the K+ channel aligned with the M3 segment. M1 also overlays well with the outer helix of the K+ channel. | |||
==Details of Structure Featured== | ==Details of Structure Featured== | ||
| Line 179: | Line 181: | ||
* [[1gr2]] – Structure of a glutamate-receptor ligand-binding core in complex with kainate<ref>PMID: 9804426</ref> | * [[1gr2]] – Structure of a glutamate-receptor ligand-binding core in complex with kainate<ref>PMID: 9804426</ref> | ||
* [[3jpy]] and [[3jpw]] – Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit<ref name="r22" /> | * [[3jpy]] and [[3jpw]] – Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit<ref name="r22" /> | ||
* [[1iiw]] and [[1iit]] and [[1ii5]] – Prokaryotic glutamte receptor (Glur0) Apo structure and with various ligands bound, including glutmate <ref>PMID: 10617203</ref>. This helped cement the notion the glutamate and potassium receptors share structural similarity and possibly evolutionary ancestry <ref | * [[1iiw]] and [[1iit]] and [[1ii5]] – Prokaryotic glutamte receptor (Glur0) Apo structure and with various ligands bound, including glutmate <ref>PMID: 10617203</ref>. This helped cement the notion the glutamate and potassium receptors share structural similarity and possibly evolutionary ancestry <ref name="pot1" /><ref name="pot2" />. | ||
* [[3hgh]] and [[3hgh]] – The N-terminal domain of a GluR6-subtype glutamate receptor<ref name="r14" /> | * [[3hgh]] and [[3hgh]] – The N-terminal domain of a GluR6-subtype glutamate receptor<ref name="r14" /> | ||
* [[1bl8]] and [[1jq1]] and [[1jq2]] – ''Streptomyces lividans'' KcsA potassium channel<ref | * [[1bl8]] and [[1jq1]] and [[1jq2]] – ''Streptomyces lividans'' KcsA potassium channel<ref name="pot3" /><ref>PMID:11573095</ref>: The M1, M2 and M3 segments of GluA2's ion channel overlap remarkably well with the structurally equivalent portions KcsA. | ||
* [[Molecular Playground/Glutamate Receptor]] | * [[Molecular Playground/Glutamate Receptor]] | ||
