3k05: Difference between revisions

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{{Seed}}
[[Image:3k05.png|left|200px]]
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{{STRUCTURE_3k05|  PDB=3k05  |  SCENE=  }}  
{{STRUCTURE_3k05|  PDB=3k05  |  SCENE=  }}  
===The crystal structure of MDC1 BRCT T2067D in complex with a minimal recognition tetrapeptide with an amidated C-terminus===
===The crystal structure of MDC1 BRCT T2067D in complex with a minimal recognition tetrapeptide with an amidated C-terminus===
{{ABSTRACT_PUBMED_20159462}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/MDC1_HUMAN MDC1_HUMAN]] Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.<ref>PMID:14695167</ref><ref>PMID:12475977</ref><ref>PMID:12499369</ref><ref>PMID:12551934</ref><ref>PMID:12611903</ref><ref>PMID:12607003</ref><ref>PMID:12607004</ref><ref>PMID:12607005</ref><ref>PMID:15201865</ref><ref>PMID:15377652</ref>  
The line below this paragraph, {{ABSTRACT_PUBMED_20159462}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20159462 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20159462}}


==About this Structure==
==About this Structure==
3K05 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K05 OCA].  
[[3k05]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K05 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20159462</ref><references group="xtra"/>
<ref group="xtra">PMID:020159462</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Campbell, S J.]]
[[Category: Campbell, S J.]]
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[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Protein-peptide complex]]
[[Category: Protein-peptide complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:12:29 2010''
Retrieved from "https://proteopedia.org/3k05"