3ngn: Difference between revisions

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{{Seed}}
[[Image:3ngn.jpg|left|200px]]
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{{STRUCTURE_3ngn|  PDB=3ngn  |  SCENE=  }}  
{{STRUCTURE_3ngn|  PDB=3ngn  |  SCENE=  }}  
===Crystal structure of the human CNOT6L nuclease domain in complex with AMP===
===Crystal structure of the human CNOT6L nuclease domain in complex with AMP===
{{ABSTRACT_PUBMED_20628353}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN]] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.<ref>PMID:17452450</ref>
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{{ABSTRACT_PUBMED_20628353}}


==About this Structure==
==About this Structure==
3NGN is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGN OCA].  
[[3ngn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGN OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20628353</ref><references group="xtra"/>
<ref group="xtra">PMID:020628353</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bartlam, M.]]
[[Category: Bartlam, M.]]
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Protein-amp complex]]
[[Category: Protein-amp complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:42:07 2010''

Revision as of 12:05, 24 April 2013

Template:STRUCTURE 3ngn

Crystal structure of the human CNOT6L nuclease domain in complex with AMP

Template:ABSTRACT PUBMED 20628353

Function

[CNO6L_HUMAN] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.[1]

About this Structure

3ngn is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Wang H, Morita M, Yang X, Suzuki T, Yang W, Wang J, Ito K, Wang Q, Zhao C, Bartlam M, Yamamoto T, Rao Z. Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity. EMBO J. 2010 Aug 4;29(15):2566-76. Epub 2010 Jul 13. PMID:20628353 doi:10.1038/emboj.2010.152
  1. ↑ Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T. Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth. Mol Cell Biol. 2007 Jul;27(13):4980-90. Epub 2007 Apr 23. PMID:17452450 doi:MCB.02304-06

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