3ngo: Difference between revisions
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{{STRUCTURE_3ngo| PDB=3ngo | SCENE= }} | {{STRUCTURE_3ngo| PDB=3ngo | SCENE= }} | ||
===Crystal structure of the human CNOT6L nuclease domain in complex with poly(A) DNA=== | ===Crystal structure of the human CNOT6L nuclease domain in complex with poly(A) DNA=== | ||
{{ABSTRACT_PUBMED_20628353}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN]] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.<ref>PMID:17452450</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3ngo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGO OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020628353</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Bartlam, M.]] | [[Category: Bartlam, M.]] | ||
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[[Category: Hydrolase-dna complex]] | [[Category: Hydrolase-dna complex]] | ||
[[Category: Protein-ssdna complex]] | [[Category: Protein-ssdna complex]] | ||