3l0y: Difference between revisions
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{{STRUCTURE_3l0y| PDB=3l0y | SCENE= }} | {{STRUCTURE_3l0y| PDB=3l0y | SCENE= }} | ||
===Crystal structure OF SCP1 phosphatase D98A mutant=== | ===Crystal structure OF SCP1 phosphatase D98A mutant=== | ||
{{ABSTRACT_PUBMED_20222012}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CTDS1_HUMAN CTDS1_HUMAN]] Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.<ref>PMID:12721286</ref> <ref>PMID:15681389</ref> | |||
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==About this Structure== | ==About this Structure== | ||
[[3l0y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0Y OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020222012</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Phosphoprotein phosphatase]] | [[Category: Phosphoprotein phosphatase]] | ||
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[[Category: Protein phosphatase]] | [[Category: Protein phosphatase]] | ||
[[Category: Small c-terminal domain phosphatase]] | [[Category: Small c-terminal domain phosphatase]] | ||