3l0y: Difference between revisions

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{{Seed}}
[[Image:3l0y.png|left|200px]]
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{{STRUCTURE_3l0y|  PDB=3l0y  |  SCENE=  }}  
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===Crystal structure OF SCP1 phosphatase D98A mutant===
===Crystal structure OF SCP1 phosphatase D98A mutant===
{{ABSTRACT_PUBMED_20222012}}


 
==Function==
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[[http://www.uniprot.org/uniprot/CTDS1_HUMAN CTDS1_HUMAN]] Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.<ref>PMID:12721286</ref> <ref>PMID:15681389</ref> 
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{{ABSTRACT_PUBMED_20222012}}


==About this Structure==
==About this Structure==
3L0Y is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0Y OCA].  
[[3l0y]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0Y OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20222012</ref><references group="xtra"/>
<ref group="xtra">PMID:020222012</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Phosphoprotein phosphatase]]
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[[Category: Protein phosphatase]]
[[Category: Protein phosphatase]]
[[Category: Small c-terminal domain phosphatase]]
[[Category: Small c-terminal domain phosphatase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:08:42 2010''