3lf0: Difference between revisions
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{{STRUCTURE_3lf0| PDB=3lf0 | SCENE= }} | {{STRUCTURE_3lf0| PDB=3lf0 | SCENE= }} | ||
===Crystal structure of the ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein=== | ===Crystal structure of the ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein=== | ||
{{ABSTRACT_PUBMED_20521335}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GLNB_MYCTU GLNB_MYCTU]] In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed (By similarity). | |||
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==About this Structure== | ==About this Structure== | ||
[[3lf0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LF0 OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020521335</ref><references group="xtra"/><references/> | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Owen, J L.]] | [[Category: Owen, J L.]] | ||
| Line 45: | Line 32: | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
Revision as of 20:35, 4 April 2013
Crystal structure of the ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein
Template:ABSTRACT PUBMED 20521335
Function
[GLNB_MYCTU] In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP. P-II-UMP allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme. Conversely, in nitrogen excess P-II is deuridylated and promotes the adenylation of GS. P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is uridylylated to P-II-UMP, these events are reversed (By similarity).
About this Structure
3lf0 is a 3 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- Shetty ND, Reddy MC, Palaninathan SK, Owen JL, Sacchettini JC. Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein. Protein Sci. 2010 Aug;19(8):1513-24. PMID:20521335 doi:10.1002/pro.430
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Mycobacterium tuberculosis
- Owen, J L.
- Palaninathan, S K.
- Reddy, M C.M.
- Sacchettini, J C.
- Shetty, N D.
- TBSGC, TB Structural Genomics Consortium.
- 3-10 helix
- B-loop
- C-loop
- Glnb
- Glnk
- Nucleotide-binding
- Pii protein
- Signaling protein-transcription complex
- Structural genomic
- T-loop
- Tb structural genomics consortium
- Tbsgc
- Transcription
- Transcription regulation
