3m6a: Difference between revisions
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{{STRUCTURE_3m6a| PDB=3m6a | SCENE= }} | {{STRUCTURE_3m6a| PDB=3m6a | SCENE= }} | ||
===Crystal structure of Bacillus subtilis Lon C-terminal domain=== | ===Crystal structure of Bacillus subtilis Lon C-terminal domain=== | ||
{{ABSTRACT_PUBMED_20600124}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LON1_BACSU LON1_BACSU]] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). Has been implicated in preventing sigma(G) activity under non-sporulation conditions.[HAMAP-Rule:MF_01973] | |||
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==About this Structure== | ==About this Structure== | ||
[[3m6a]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M6A OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020600124</ref><references group="xtra"/><references/> | ||
[[Category: Bacillus subtilis]] | [[Category: Bacillus subtilis]] | ||
[[Category: Endopeptidase La]] | [[Category: Endopeptidase La]] | ||
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[[Category: Serine protease]] | [[Category: Serine protease]] | ||
[[Category: Stress response]] | [[Category: Stress response]] | ||
Revision as of 23:31, 10 April 2013
Crystal structure of Bacillus subtilis Lon C-terminal domain
Template:ABSTRACT PUBMED 20600124
Function
[LON1_BACSU] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). Has been implicated in preventing sigma(G) activity under non-sporulation conditions.[HAMAP-Rule:MF_01973]
About this Structure
3m6a is a 6 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
- Duman RE, Lowe J. Crystal structures of Bacillus subtilis Lon protease. J Mol Biol. 2010 Aug 27;401(4):653-70. Epub 2010 Jun 19. PMID:20600124 doi:10.1016/j.jmb.2010.06.030
