Angiotensin-Converting Enzyme: Difference between revisions
From Proteopedia
Jump to navigationJump to search
David Canner (talk | contribs) No edit summary |
David Canner (talk | contribs) No edit summary |
||
| Line 7: | Line 7: | ||
==Biological Role== | ==Biological Role== | ||
[[Image: Renin_system.png| | [[Image: Renin_system.png|450px|left|thumb| Renin-Angiotensin-Aldosterone System Schematic]] | ||
ACE is a Zn and Chloride dependent type-1 membrane protein (N-terminal regions are outside the cell). Two types of Angiotensin-converting enzyme exist, ACE1 and ACE2, although the most focus has been on ACE1 which has been attributed with receptor-mediated effects like vasoconstriction, inflammation and cell growth/proliferation. <ref name="Ferrario">PMID:17083068</ref> The Renin-Angiotensin System (RAS) is a major regulator of blood pressure in the human body. [[Renin]] is an enzyme produced by the liver which cleaves Angiotensinogen into Angiotensin I Angiotensin Ihas the sequence, DRVTIHPFHL, and does not appear to have any biological activity. Angiotensin 1 is converted into Angiotensin II via the removal of the two C-terminal residues by ACE, yielding the active peptide: DRVTIHPF. <ref>PMID:12752436</ref> | ACE is a Zn and Chloride dependent type-1 membrane protein (N-terminal regions are outside the cell). Two types of Angiotensin-converting enzyme exist, ACE1 and ACE2, although the most focus has been on ACE1 which has been attributed with receptor-mediated effects like vasoconstriction, inflammation and cell growth/proliferation. <ref name="Ferrario">PMID:17083068</ref> The Renin-Angiotensin System (RAS) is a major regulator of blood pressure in the human body. [[Renin]] is an enzyme produced by the liver which cleaves Angiotensinogen into Angiotensin I Angiotensin Ihas the sequence, DRVTIHPFHL, and does not appear to have any biological activity. Angiotensin 1 is converted into Angiotensin II via the removal of the two C-terminal residues by ACE, yielding the active peptide: DRVTIHPF. <ref>PMID:12752436</ref> | ||
| Line 13: | Line 13: | ||
<br /> | <br /> | ||
{| class="wikitable" border="1" width=" | {| class="wikitable" border="1" width="50%" style="text-align:center" | ||
|- | |- | ||
! colspan="2" align="center"| Selected AT1 and AT2 Receptor-Mediated Effects of Angiotensin II. <ref name="Weir"/><ref name="Ferrario"/> | ! colspan="2" align="center"| Selected AT1 and AT2 Receptor-Mediated Effects of Angiotensin II. <ref name="Weir"/><ref name="Ferrario"/> | ||
