3l2a: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
{{Seed}}
[[Image:3l2a.png|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_3l2a", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_3l2a|  PDB=3l2a  |  SCENE=  }}  
{{STRUCTURE_3l2a|  PDB=3l2a  |  SCENE=  }}  
===Crystal structure of Reston Ebola VP35 interferon inhibitory domain===
===Crystal structure of Reston Ebola VP35 interferon inhibitory domain===
{{ABSTRACT_PUBMED_20399790}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/VP35_EBORR VP35_EBORR]] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. The mechanism by which this blockage occurs remains incompletely defined, a hypothesis suggests that VP35 dsRNA-binding activity prevents activation of IRF3 by sequestering dsRNA. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).
The line below this paragraph, {{ABSTRACT_PUBMED_20399790}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20399790 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_20399790}}


==About this Structure==
==About this Structure==
3L2A is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2A OCA].  
[[3l2a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2A OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20399790</ref><references group="xtra"/>
<ref group="xtra">PMID:020399790</ref><references group="xtra"/><references/>
[[Category: Reston ebolavirus]]
[[Category: Reston ebolavirus]]
[[Category: Amarasinghe, G K.]]
[[Category: Amarasinghe, G K.]]
Line 40: Line 27:
[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Virion]]
[[Category: Virion]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:03:44 2010''
Retrieved from "https://proteopedia.org/3l2a"