3k33: Difference between revisions

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{{Seed}}
[[Image:3k33.jpg|left|200px]]
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{{STRUCTURE_3k33|  PDB=3k33  |  SCENE=  }}  
{{STRUCTURE_3k33|  PDB=3k33  |  SCENE=  }}  
===Crystal structure of the Phd-Doc complex===
===Crystal structure of the Phd-Doc complex===
{{ABSTRACT_PUBMED_20603017}}


 
==Function==
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[[http://www.uniprot.org/uniprot/DOC_BPP1 DOC_BPP1]] Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures and a decrease in colony formation by inhibiting translation, stabilizing mRNA and polysomes; these effects are overcome by concomitant expression of antitoxin phd. Binds 70S ribosomes and the 30S ribosomal subunits, the binding site is the same as for the antibiotic hygromycin B. Bacteriophage P1 lysogenizes bacteria as a low-copy number plasmid. Doc and phd proteins function in unison to stabilize plasmid number by inducing a lethal response to P1 plasmid prophage loss. Overexpression of doc can induce the mRNA interferase activity of RelE in vivo.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref>  Antitoxin phd binds to its own promoter repressing its expression; toxin doc acts as a corepressor or derepressor depending on the ratio, repressing or inducing expression.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref>  [[http://www.uniprot.org/uniprot/PHD_BPP1 PHD_BPP1]] Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that binds to the doc toxin and neutralizes its toxic effect. Bacteriophage P1 lysogenizes bacteria as a low-copy number plasmid. Phd and doc proteins function in unison to stabilize plasmid number by inducing a lethal response to P1 plasmid prophage loss.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref>  Binds to its own promoter repressing its expression; toxin doc acts as a corepressor or derepressor depending on the ratio, repressing or inducing expression.<ref>PMID:9829946</ref> <ref>PMID:18398006</ref>
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{{ABSTRACT_PUBMED_20603017}}


==About this Structure==
==About this Structure==
3K33 is a 5 chains structure with sequences from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p1 Enterobacteria phage p1] and [http://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K33 OCA].  
[[3k33]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p1 Enterobacteria phage p1] and [http://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K33 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20603017</ref><references group="xtra"/>
<ref group="xtra">PMID:020603017</ref><references group="xtra"/><references/>
[[Category: Enterobacteria phage p1]]
[[Category: Enterobacteria phage p1]]
[[Category: Unidentified]]
[[Category: Unidentified]]
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[[Category: Toxin-antitoxin complex]]
[[Category: Toxin-antitoxin complex]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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Retrieved from "https://proteopedia.org/3k33"