3ixs: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,013 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,013 edits
No edit summary
Line 1: Line 1:
{{Seed}}
[[Image:3ixs.jpg|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_3ixs", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_3ixs|  PDB=3ixs  |  SCENE=  }}  
{{STRUCTURE_3ixs|  PDB=3ixs  |  SCENE=  }}  
===Ring1B C-terminal domain/RYBP C-terminal domain Complex===
===Ring1B C-terminal domain/RYBP C-terminal domain Complex===
{{ABSTRACT_PUBMED_20696397}}


==Function==
[[http://www.uniprot.org/uniprot/RING2_HUMAN RING2_HUMAN]] E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity.<ref>PMID:11513855</ref><ref>PMID:15386022</ref><ref>PMID:16359901</ref><ref>PMID:16714294</ref><ref>PMID:20696397</ref>


<!--
==About this Structure==
The line below this paragraph, {{ABSTRACT_PUBMED_20696397}}, adds the Publication Abstract to the page
[[3ixs]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXS OCA].
(as it appears on PubMed at http://www.pubmed.gov), where 20696397 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_20696397}}


==About this Structure==
==See Also==
3IXS is a 12 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXS OCA].
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]


==Reference==
==Reference==
<ref group="xtra">PMID:20696397</ref><references group="xtra"/>
<ref group="xtra">PMID:020696397</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Kim, C A.]]
[[Category: Kim, C A.]]
Line 47: Line 37:
[[Category: Ubl conjugation pathway]]
[[Category: Ubl conjugation pathway]]
[[Category: Zinc-finger]]
[[Category: Zinc-finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:55:06 2010''
Retrieved from "https://proteopedia.org/3ixs"