3kg5: Difference between revisions

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{{Seed}}
[[Image:3kg5.jpg|left|200px]]
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{{STRUCTURE_3kg5|  PDB=3kg5  |  SCENE=  }}  
{{STRUCTURE_3kg5|  PDB=3kg5  |  SCENE=  }}  
===Crystal structure of human Ig-beta homodimer===
===Crystal structure of human Ig-beta homodimer===
{{ABSTRACT_PUBMED_20696394}}


==Disease==
[[http://www.uniprot.org/uniprot/CD79B_HUMAN CD79B_HUMAN]] Autosomal agammaglobulinemia. Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:[http://omim.org/entry/612692 612692]]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.<ref>PMID:17675462</ref> 


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==Function==
The line below this paragraph, {{ABSTRACT_PUBMED_20696394}}, adds the Publication Abstract to the page
[[http://www.uniprot.org/uniprot/CD79B_HUMAN CD79B_HUMAN]] Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.<ref>PMID:8617796</ref> <ref>PMID:9057631</ref> <ref>PMID:12097390</ref>
(as it appears on PubMed at http://www.pubmed.gov), where 20696394 is the PubMed ID number.
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{{ABSTRACT_PUBMED_20696394}}


==About this Structure==
==About this Structure==
3KG5 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG5 OCA].  
[[3kg5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG5 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20696394</ref><references group="xtra"/>
<ref group="xtra">PMID:020696394</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Radaev, S.]]
[[Category: Radaev, S.]]
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[[Category: Immunoglobulin domain]]
[[Category: Immunoglobulin domain]]
[[Category: Protein binding]]
[[Category: Protein binding]]
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Retrieved from "https://proteopedia.org/3kg5"