3nry: Difference between revisions
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{{STRUCTURE_3nry| PDB=3nry | SCENE= }} | {{STRUCTURE_3nry| PDB=3nry | SCENE= }} | ||
===Insights into anti-parallel microtubule crosslinking by PRC1, a conserved microtubule binding protein=== | ===Insights into anti-parallel microtubule crosslinking by PRC1, a conserved microtubule binding protein=== | ||
{{ABSTRACT_PUBMED_20691902}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PRC1_HUMAN PRC1_HUMAN]] Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle.<ref>PMID:9885575</ref> <ref>PMID:12082078</ref> <ref>PMID:15297875</ref> <ref>PMID:15625105</ref> <ref>PMID:16431929</ref> <ref>PMID:19468300</ref> <ref>PMID:20691902</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3nry]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NRY OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020691902</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arthur, C P.]] | [[Category: Arthur, C P.]] | ||
| Line 36: | Line 23: | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Spectrin fold]] | [[Category: Spectrin fold]] | ||