3n6o: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,609 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,609 edits
No edit summary
Line 1: Line 1:
{{Seed}}
[[Image:3n6o.png|left|200px]]
<!--
The line below this paragraph, containing "STRUCTURE_3n6o", creates the "Structure Box" on the page.
You may change the PDB parameter (which sets the PDB file loaded into the applet)
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
or leave the SCENE parameter empty for the default display.
-->
{{STRUCTURE_3n6o|  PDB=3n6o  |  SCENE=  }}  
{{STRUCTURE_3n6o|  PDB=3n6o  |  SCENE=  }}  
===Crystal structure of the GEF and P4M domain of DrrA/SidM from Legionella pneumophila===
===Crystal structure of the GEF and P4M domain of DrrA/SidM from Legionella pneumophila===
{{ABSTRACT_PUBMED_20616805}}


 
==Function==
<!--  
[[http://www.uniprot.org/uniprot/Q5ZSQ3_LEGPH Q5ZSQ3_LEGPH]] Virulence effector that plays a key role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a GDP-GTP exchange factor (GEF) for the small GTPase Rab1 (RAB1A, RAB1B or RAB1C), thereby converting Rab1 to an active GTP-bound state, leading to the incorporation of Rab1 into LCVs. Also shows RabGDI displacement factor (GDF) activity; however, this probably represents a passive activity following the GEF activity. Also acts as an adenylyltransferase by mediating the addition of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby rendering RAB1B constitutively active. Also has adenylyltransferase activity towards Rab6 and Rab35. Also displays guanylyltransferase activity by mediating the addition of guanosine 5'-monophosphate (GMP) to host RAB1B in vitro; however such activity remains uncertain in vivo. Specifically binds phosphatidylinositol 4-phosphate (PtdIns(4)P) lipids on the cytosolic surface of the phagosomal membrane shortly after infection.<ref>PMID:16824952</ref> <ref>PMID:17947549</ref> <ref>PMID:21822290</ref> <ref>PMID:20064470</ref> <ref>PMID:19942850</ref> <ref>PMID:20176951</ref>
The line below this paragraph, {{ABSTRACT_PUBMED_20616805}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20616805 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_20616805}}


==About this Structure==
==About this Structure==
3N6O is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6O OCA].  
[[3n6o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6O OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20616805</ref><references group="xtra"/>
<ref group="xtra">PMID:020616805</ref><references group="xtra"/><references/>
[[Category: Legionella pneumophila]]
[[Category: Legionella pneumophila]]
[[Category: Blankenfeldt, W.]]
[[Category: Blankenfeldt, W.]]
Line 37: Line 24:
[[Category: Rabgef]]
[[Category: Rabgef]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:26:14 2010''
Retrieved from "https://proteopedia.org/3n6o"