3o4z: Difference between revisions
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{{STRUCTURE_3o4z| PDB=3o4z | SCENE= }} | {{STRUCTURE_3o4z| PDB=3o4z | SCENE= }} | ||
===Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes=== | ===Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes=== | ||
{{ABSTRACT_PUBMED_20801936}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TEL2_YEAST TEL2_YEAST]] Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats. | |||
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==About this Structure== | ==About this Structure== | ||
[[3o4z]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4Z OCA]. | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020801936</ref><references group="xtra"/><references/> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Pavletich, N P.]] | [[Category: Pavletich, N P.]] | ||
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[[Category: Heat like helical repeat]] | [[Category: Heat like helical repeat]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
Revision as of 11:57, 24 April 2013
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
Template:ABSTRACT PUBMED 20801936
Function
[TEL2_YEAST] Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins (By similarity). Required for telomere length regulation and telomere position effect. Regulates telomere length and participates in gene silencing at subtelomeric regions. Binds to telomeric DNA repeats.
About this Structure
3o4z is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
- Takai H, Xie Y, de Lange T, Pavletich NP. Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes. Genes Dev. 2010 Aug 27. PMID:20801936 doi:10.1101/gad.1956410
