3n7p: Difference between revisions

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{{Seed}}
[[Image:3n7p.png|left|200px]]
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{{STRUCTURE_3n7p|  PDB=3n7p  |  SCENE=  }}  
{{STRUCTURE_3n7p|  PDB=3n7p  |  SCENE=  }}  
===Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism===
===Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism===
{{ABSTRACT_PUBMED_20826335}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/RAMP1_HUMAN RAMP1_HUMAN]] Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.<ref>PMID:9620797</ref>
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{{ABSTRACT_PUBMED_20826335}}


==About this Structure==
==About this Structure==
3N7P is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7P OCA].  
[[3n7p]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N7P OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:20826335</ref><references group="xtra"/>
<ref group="xtra">PMID:020826335</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Haar, E Ter.]]
[[Category: Haar, E Ter.]]
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[[Category: Olcegepant]]
[[Category: Olcegepant]]
[[Category: Telcagepant]]
[[Category: Telcagepant]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:23:01 2010''

Revision as of 21:07, 17 April 2013

Template:STRUCTURE 3n7p

Crystal structure of the ectodomain complex of the CGRP receptor, a Class-B GPCR, reveals the site of drug antagonism

Template:ABSTRACT PUBMED 20826335

Function

[RAMP1_HUMAN] Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.[1]

About this Structure

3n7p is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM. Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure. 2010 Sep 8;18(9):1083-93. PMID:20826335 doi:10.1016/j.str.2010.05.014
  1. ↑ McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9. PMID:9620797 doi:10.1038/30666

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