3nih: Difference between revisions
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{{STRUCTURE_3nih| PDB=3nih | SCENE= }} | {{STRUCTURE_3nih| PDB=3nih | SCENE= }} | ||
===The structure of UBR box (RIAAA)=== | ===The structure of UBR box (RIAAA)=== | ||
{{ABSTRACT_PUBMED_20835240}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/UBR1_YEAST UBR1_YEAST]] Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. | |||
==About this Structure== | |||
[[3nih]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NIH OCA]. | |||
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== | ==See Also== | ||
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]] | |||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID: | <ref group="xtra">PMID:020835240</ref><references group="xtra"/><references/> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Choi, W S.]] | [[Category: Choi, W S.]] | ||
| Line 35: | Line 25: | ||
[[Category: Ubr box]] | [[Category: Ubr box]] | ||
[[Category: Zinc-binding protein]] | [[Category: Zinc-binding protein]] | ||
Revision as of 12:09, 24 April 2013
The structure of UBR box (RIAAA)
Template:ABSTRACT PUBMED 20835240
Function
[UBR1_YEAST] Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
About this Structure
3nih is a 2 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
See Also
Reference
- Choi WS, Jeong BC, Joo YJ, Lee MR, Kim J, Eck MJ, Song HK. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases. Nat Struct Mol Biol. 2010 Sep 12. PMID:20835240 doi:10.1038/nsmb.1907