1usn: Difference between revisions

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[[Image:1usn.jpg|left|200px]]<br /><applet load="1usn" size="450" color="white" frame="true" align="right" spinBox="true"  
[[Image:1usn.jpg|left|200px]]<br /><applet load="1usn" size="350" color="white" frame="true" align="right" spinBox="true"  
caption="1usn, resolution 1.8&Aring;" />
caption="1usn, resolution 1.8&Aring;" />
'''CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-142372'''<br />
'''CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN FIBROBLAST STROMELYSIN-1 INHIBITED WITH THIADIAZOLE INHIBITOR PNU-142372'''<br />
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==About this Structure==
==About this Structure==
1USN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:ZINC ION'>ZN</scene>, <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> and <scene name='pdbligand=IN9:2-[3-(5-MERCAPTO-[1,3,4]THIADIAZOL-2YL)-UREIDO]-N-METHYL-3-PENTAFLUOROPHENYL-PROPIONAMIDE'>IN9</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Known structural/functional Sites: <scene name='pdbsite=CA1:Ca1 Are The Ligands Of Ca Ion Ca 259'>CA1</scene>, <scene name='pdbsite=CA2:Ca2 Are The Ligands Of Ca Ion Ca 260'>CA2</scene>, <scene name='pdbsite=CA3:Ca3 Are The Ligands Of Ca Ion Ca 261'>CA3</scene>, <scene name='pdbsite=INH:Site Inh Is The Binding Site For The Urea-Thiadiazole In ...'>INH</scene>, <scene name='pdbsite=ZN1:Zn1 Are The Ligands Of Catalytic (Zn 257) Zn Ion'>ZN1</scene> and <scene name='pdbsite=ZN2:Zn2 Are The Ligands Of Structural (Zn 258) Zn Ion'>ZN2</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1USN OCA].  
1USN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=IN9:'>IN9</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Known structural/functional Sites: <scene name='pdbsite=CA1:Ca1+Are+The+Ligands+Of+Ca+Ion+Ca+259'>CA1</scene>, <scene name='pdbsite=CA2:Ca2+Are+The+Ligands+Of+Ca+Ion+Ca+260'>CA2</scene>, <scene name='pdbsite=CA3:Ca3+Are+The+Ligands+Of+Ca+Ion+Ca+261'>CA3</scene>, <scene name='pdbsite=INH:Site+Inh+Is+The+Binding+Site+For+The+Urea-Thiadiazole+In+...'>INH</scene>, <scene name='pdbsite=ZN1:Zn1+Are+The+Ligands+Of+Catalytic+(Zn+257)+Zn+Ion'>ZN1</scene> and <scene name='pdbsite=ZN2:Zn2+Are+The+Ligands+Of+Structural+(Zn+258)+Zn+Ion'>ZN2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1USN OCA].  


==Reference==
==Reference==
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[[Category: metalloprotease]]
[[Category: metalloprotease]]


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