2qr8: Difference between revisions

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==Overview==

The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2, C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix, that was embedded in the kinase scaffold and determines the inactive, kinase conformation. We suggest a mechanism of activation through, displacement of the alphaL-helix and rearrangement of the conserved, residue Glu500, as well as the reorganization of the T-loop into the, active conformation.

The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.

==About this Structure==

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[[Category: transferase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Jan 23 10~~:44:00 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:41:36 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2, C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix, that was embedded in the kinase scaffold and determines the inactive, kinase conformation. We suggest a mechanism of activation through, displacement of the alphaL-helix and rearrangement of the conserved, residue Glu500, as well as the reorganization of the T-loop into the, active conformation.
+The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.
 ==About this Structure==
@@ Line 27: / Line 27: @@
 [[Category: transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 10:44:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:41:36 2008''