2jwa: Difference between revisions
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New page: left|200px<br /><applet load="2jwa" size="350" color="white" frame="true" align="right" spinBox="true" caption="2jwa" /> '''ErbB2 transmembrane segment dimer spatial st... |
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==Overview== | ==Overview== | ||
Proper lateral dimerization of transmembrane domain of receptor tyrosine | Proper lateral dimerization of transmembrane domain of receptor tyrosine kinases is required for biochemical signal transduction across plasma membrane. Spatial structure of dimeric transmembrane domain of the growth factor receptor ErbB2 embedded into lipid bicelle was obtained by solution NMR followed by molecular dynamics relaxation in explicit lipid bilayer. ErbB2 transmembrane segments associate in a right-handed alpha-helical bundle through the N-terminal tandem GG4-like motif T(652)X(3)S(656)X(3)G(660), providing explanation for pathogenic power of some oncogenic mutations. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Arseniev, A | [[Category: Arseniev, A S.]] | ||
[[Category: Bocharov, E | [[Category: Bocharov, E V.]] | ||
[[Category: Mineev, K | [[Category: Mineev, K S.]] | ||
[[Category: atp-binding]] | [[Category: atp-binding]] | ||
[[Category: erbb2]] | [[Category: erbb2]] | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:06:18 2008'' | ||
