2ole: Difference between revisions

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==Overview==

Inhibitors of dipeptidyl peptidase IV (DPP-IV) have been shown to be, effective treatments for type 2 diabetes. A series of, beta-aminoacyl-containing cyclic hydrazine derivatives were synthesized, and evaluated as DPP-IV inhibitors. One member of this series, (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl)butan, -1-one (10f), showed potent in vitro activity, good selectivity and in, vivo efficacy in mouse models. Also, the binding mode of compound 10f was, determined by X-ray crystallography.

Inhibitors of dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes. A series of beta-aminoacyl-containing cyclic hydrazine derivatives were synthesized and evaluated as DPP-IV inhibitors. One member of this series, (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl)butan -1-one (10f), showed potent in vitro activity, good selectivity and in vivo efficacy in mouse models. Also, the binding mode of compound 10f was determined by X-ray crystallography.

==About this Structure==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Ahn, J.H.]]

[[Category: Ahn, J H.]]

[[Category: Kim, S.S.]]

[[Category: Kim, S S.]]

[[Category: Lee, J.O.]]

[[Category: Lee, J O.]]

[[Category: KR2]]

[[Category: cyclic hydrazine]]

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[[Category: hydrolase]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Inhibitors of dipeptidyl peptidase IV (DPP-IV) have been shown to be, effective treatments for type 2 diabetes. A series of, beta-aminoacyl-containing cyclic hydrazine derivatives were synthesized, and evaluated as DPP-IV inhibitors. One member of this series, (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl)butan, -1-one (10f), showed potent in vitro activity, good selectivity and in, vivo efficacy in mouse models. Also, the binding mode of compound 10f was, determined by X-ray crystallography.
+Inhibitors of dipeptidyl peptidase IV (DPP-IV) have been shown to be effective treatments for type 2 diabetes. A series of beta-aminoacyl-containing cyclic hydrazine derivatives were synthesized and evaluated as DPP-IV inhibitors. One member of this series, (R)-3-amino-1-(2-benzoyl-1,2-diazepan-1-yl)-4-(2,4,5-trifluorophenyl)butan -1-one (10f), showed potent in vitro activity, good selectivity and in vivo efficacy in mouse models. Also, the binding mode of compound 10f was determined by X-ray crystallography.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Ahn, J.H.]]
+[[Category: Ahn, J H.]]
-[[Category: Kim, S.S.]]
+[[Category: Kim, S S.]]
-[[Category: Lee, J.O.]]
+[[Category: Lee, J O.]]
 [[Category: KR2]]
 [[Category: cyclic hydrazine]]
@@ Line 23: / Line 23: @@
 [[Category: hydrolase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 10:49:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:19:50 2008''