RNA Interference: Difference between revisions
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[[Image:500px-ShRNA Lentivirus.png| | [[Image:500px-ShRNA Lentivirus.png|350px|left|thumb| Schematic of RNAi Interference in Mammalian Cells]] | ||
{{Structure | {{Structure | ||
|PDB= 3dlh |SIZE=300|SCENE=RNA_Interference/3dlh/2|CAPTION= guide-strand-containing Argonaute protein silencing complex ([[3dlh]]), resolution 3.00Å (<scene name='RNA_Interference/3dlh/2'>initial scene</scene>) | |PDB= 3dlh |SIZE=300|SCENE=RNA_Interference/3dlh/2|CAPTION= guide-strand-containing Argonaute protein silencing complex ([[3dlh]]), resolution 3.00Å (<scene name='RNA_Interference/3dlh/2'>initial scene</scene>) | ||
Revision as of 08:56, 27 September 2010
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| guide-strand-containing Argonaute protein silencing complex (3dlh), resolution 3.00Å (initial scene) | |||||||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
RNA Interference (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded RNA is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.
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| viral silencing suppressor bound to a siRNA (1rpu), resolution 2.50Å (initial scene) | |||||||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Articles in Proteopedia concerning RNA Interference include:
- Suppression of RNA Silencing by Viruses
- Plant Viral Protein p19 Supression of RNA Silencing
- Tomato aspermy virus protein 2b Suppression of RNA Silencing
- Flock house virus B2 protein Suppression of RNA Silencing
To view automatically seeded indices concerning RNA Interference See:
To view other Proteopedia pages about diseases & drug targets, See: Pharmaceutical Drug Targets
